[HTML][HTML] The microbiota of the respiratory tract: gatekeeper to respiratory health
The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …
Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity
One of the fundamental issues in the microbiome research is characterization of the healthy
human microbiota. Recent studies have elucidated substantial divergences in the …
human microbiota. Recent studies have elucidated substantial divergences in the …
[HTML][HTML] Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction
Levels of inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated. We find that, when …
underlying cause of this age-associated inflammation is debated. We find that, when …
The microbiome of the upper respiratory tract in health and disease
The human upper respiratory tract (URT) offers a variety of niches for microbial colonization.
Local microbial communities are shaped by the different characteristics of the specific …
Local microbial communities are shaped by the different characteristics of the specific …
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice
Chemicals in food are widely used leading to significant human exposure. Allura Red AC
(AR) is a highly common synthetic colorant; however, little is known about its impact on …
(AR) is a highly common synthetic colorant; however, little is known about its impact on …
The role of the local microbial ecosystem in respiratory health and disease
WAA de Steenhuijsen Piters… - … Transactions of the …, 2015 - royalsocietypublishing.org
Respiratory tract infections are a major global health concern, accounting for high morbidity
and mortality, especially in young children and elderly individuals. Traditionally, highly …
and mortality, especially in young children and elderly individuals. Traditionally, highly …
Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis
of persistent wheezing disease in children. In this study, the occurrence of acute respiratory …
of persistent wheezing disease in children. In this study, the occurrence of acute respiratory …
Early-life respiratory infections and developmental immunity determine lifelong lung health
Respiratory infections are common in infants and young children. However, the immune
system develops and matures as the child grows, thus the effects of infection during this time …
system develops and matures as the child grows, thus the effects of infection during this time …
Infection in an aging population
Highlights•One third of deaths in adults in the elderly are due to infectious disease.•Changes
in the aging immune response increase the risk of infection in the elderly.•Respiratory …
in the aging immune response increase the risk of infection in the elderly.•Respiratory …