Interstitial lung diseases (ILDs), which can arise from a broad spectrum of distinct
aetiologies, can manifest as a pulmonary complication of an underlying autoimmune and …

Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies.
Despite evidence for immune mechanisms in lung fibrosis, immunotherapies have been …

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease
characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are …

Background MicroRNAs are non-coding RNAs that negatively regulate gene networks.
Previously, we reported that systemically delivered miR-29 mimic MRG-201 reduced fibrosis …

Over the last decade, single-cell genomics has revealed remarkable heterogeneity and
plasticity of cell types in the lungs and airways. The challenge now is to understand how …

The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

Accumulation of DNA damage in the lung induces cellular senescence and promotes age-
related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the …