Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

A 2-DOF needle insertion device using inertial piezoelectric actuator

J Deng, S Liu, Y Liu, L Wang, X Gao… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Insertion into delicate tissue, such as retina vein occlusion, cell manipulation, and
vitreoretinal injection, poses challenges to surgeons and biomedical researchers due to the …

Zebrafish as a preclinical in vivo screening model for nanomedicines

S Sieber, P Grossen, J Bussmann, F Campbell… - Advanced drug delivery …, 2019 - Elsevier
The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Zebrafish embryos and larvae: a new generation of disease models and drug screens

S Ali, DL Champagne, HP Spaink… - … Research Part C …, 2011 - Wiley Online Library
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Multi-functional graphene as an in vitro and in vivo imaging probe

G Gollavelli, YC Ling - Biomaterials, 2012 - Elsevier
A strategy has been developed for the synthesis of multi-functional graphene (MFG) using
green synthetic approach and explored its biomedical application as a promising fluorescent …

Nanonewton force-controlled manipulation of biological cells using a monolithic MEMS microgripper with two-axis force feedback

K Kim, X Liu, Y Zhang, Y Sun - Journal of micromechanics and …, 2008 - iopscience.iop.org
As mechanical end-effectors, microgrippers enable the pick–transport–place of micrometer-
sized objects, such as manipulation and positioning of biological cells in an aqueous …

Microinjection in biomedical applications: An effortless autonomous omnidirectional microinjection system

S Zhuang, D Lei, X Yu, M Tong, W Lin… - IEEE Industrial …, 2023 - ieeexplore.ieee.org
Thanks to the advancements in micro-and nanomechatronics techniques, the capability to
inject foreign materials into target locations inside biosamples has become increasingly …

Robotic cell injection system with position and force control: Toward automatic batch biomanipulation

HB Huang, D Sun, JK Mills… - IEEE transactions on …, 2009 - ieeexplore.ieee.org
Biological cell injection is laborious work that requires lengthy training and suffers from a low
success rate. In this paper, a robotic cell-injection system for automatic injection of batch …

Microinjection as a tool of mechanical delivery

Y Zhang, LC Yu - Current opinion in biotechnology, 2008 - Elsevier
Microinjection to single cells has been widely used in the studies of transduction-challenged
cells, transgenic animal production, and in vitro fertilization to mechanically transfer DNAs …