Biological studies of post-traumatic stress disorder

RK Pitman, AM Rasmusson, KC Koenen… - nature Reviews …, 2012 - nature.com
Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

[HTML][HTML] The cingulum bundle: Anatomy, function, and dysfunction

EJ Bubb, C Metzler-Baddeley, JP Aggleton - … & Biobehavioral Reviews, 2018 - Elsevier
The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety

MJ Kim, RA Loucks, AL Palmer, AC Brown… - Behavioural brain …, 2011 - Elsevier
The dynamic interactions between the amygdala and the medial prefrontal cortex (mPFC)
are usefully conceptualized as a circuit that both allows us to react automatically to …

Neuroimaging of child abuse: a critical review

H Hart, K Rubia - Frontiers in human neuroscience, 2012 - frontiersin.org
Childhood maltreatment is a stressor that can lead to the development of behavior problems
and affect brain structure and function. This review summarizes the current evidence for the …

Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse

J Choi, B Jeong, ML Rohan, AM Polcari, MH Teicher - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Psychiatric sequelae of exposure to parental verbal abuse (PVA) appear to
be comparable with that of nonfamilial sexual abuse and witnessing domestic violence …

Effect of early institutionalization and foster care on long-term white matter development: a randomized clinical trial

J Bick, T Zhu, C Stamoulis, NA Fox, C Zeanah… - JAMA …, 2015 - jamanetwork.com
Importance Severe neglect in early life is associated with compromises in brain
development and associated behavioral functioning. Although early intervention has been …

Frontal cortical and subcortical projections provide a basis for segmenting the cingulum bundle: implications for neuroimaging and psychiatric disorders

SR Heilbronner, SN Haber - Journal of Neuroscience, 2014 - Soc Neuroscience
The cingulum bundle (CB) is one of the brain's major white matter pathways, linking regions
associated with executive function, decision-making, and emotion. Neuroimaging has …

White matter integrity and its relationship to PTSD and childhood trauma—A systematic review and meta‐analysis

JK Daniels, JP Lamke, M Gaebler… - Depression and …, 2013 - Wiley Online Library
Recent reviews and meta‐analyses reported structural gray matter changes in patients
suffering from adult‐onset posttraumatic stress disorder (PTSD) and in subjects with and …

Using the single prolonged stress model to examine the pathophysiology of PTSD

RR Souza, LJ Noble, CK McIntyre - Frontiers in pharmacology, 2017 - frontiersin.org
The endurance of memories of emotionally arousing events serves the adaptive role of
minimizing future exposure to danger and reinforcing rewarding behaviors. However …

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

EL Dennis, SG Disner, N Fani, LE Salminen… - Molecular …, 2021 - nature.com
A growing number of studies have examined alterations in white matter organization in
people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results …