Mechanisms of cisplatin-induced ototoxicity and otoprotection
Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …
chemotherapeutic agent in cancer patients has stimulated research into the causes and …
Breaking barriers to novel analgesic drug development
Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
S Maksimovic, M Nakatani, Y Baba, AM Nelson… - Nature, 2014 - nature.com
Touch submodalities, such as flutter and pressure, are mediated by somatosensory afferents
whose terminal specializations extract tactile features and encode them as action potential …
whose terminal specializations extract tactile features and encode them as action potential …
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
B Pan, C Askew, A Galvin, S Heman-Ackah… - Nature …, 2017 - nature.com
Because there are currently no biological treatments for hearing loss, we sought to advance
gene therapy approaches to treat genetic deafness. We focused on Usher syndrome, a …
gene therapy approaches to treat genetic deafness. We focused on Usher syndrome, a …
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
WH Yeh, O Shubina-Oleinik, JM Levy, B Pan… - Science translational …, 2020 - science.org
Most genetic diseases arise from recessive point mutations that require correction, rather
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …
than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to …
[HTML][HTML] Gap junctions
Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
The inner ear contains sensory epithelia that detect head movements, gravity and sound. It
is unclear how to develop these sensory epithelia from pluripotent stem cells, a process that …
is unclear how to develop these sensory epithelia from pluripotent stem cells, a process that …
[HTML][HTML] TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
KY Kwan, AJ Allchorne, MA Vollrath, AP Christensen… - Neuron, 2006 - cell.com
TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is
expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has …
expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has …
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …
Tmc gene therapy restores auditory function in deaf mice
C Askew, C Rochat, B Pan, Y Asai, H Ahmed… - Science translational …, 2015 - science.org
Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are
no biologic treatments currently available. To investigate gene therapy as a potential …
no biologic treatments currently available. To investigate gene therapy as a potential …