R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Although a considerable portion of eukaryotic genomes is transcribed as long noncoding
RNAs (lncRNAs), the vast majority are functionally uncharacterised. The rapidly expanding …

HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …

Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal
brain tumours with a universally poor prognosis. Here we collected 193 primary ETMRs and …

Aggressive cancers often have activating mutations in growth-controlling oncogenes and
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …

Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …

The impact of R-loops on the physiology and pathology of chromosomes has been
demonstrated extensively by chromatin biology research. The progress in this field has been …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

R-loops, three-stranded DNA-DNA: RNA hybrid structures, are best known for their
deleterious effects on genome stability. The regulatory factors of this fundamental genetic …

Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique
transcriptional response is initiated by hypoxia which includes the rapid activation of …