Maternal vascular adaptation to pregnancy is critically important in order to expand the
capacity for blood flow through the uteroplacental unit to meet the needs of the develo** …

Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical
roles in embryonic development, co-ordinated contraction of excitable cells, tissue …

Gap junctions, composed of proteins from the connexin gene family, are highly dynamic
structures that are regulated by kinase-mediated signaling pathways and interactions with …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and
thus have been proposed to play a role in gap junctional intercellular communication …

Cxs (connexins), the protein subunits forming gap junction intercellular communication
channels, are transported to the plasma membrane after oligomerizing into hexameric …