Innate or adaptive immunity? The example of natural killer cells
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK …
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK …
Human NK cells: surface receptors, inhibitory checkpoints, and translational applications
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion
F Locatelli, P Merli, D Pagliara, G Li Pira… - Blood, The Journal …, 2017 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-haploidentical
relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either …
relative (haplo-HSCT) is a suitable option for children with acute leukemia (AL) either …
HLA-C–Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1
JM Venstrom, G Pittari, TA Gooley… - … England Journal of …, 2012 - Mass Medical Soc
Background Of the cancers treated with allogeneic hematopoietic stem-cell transplantation
(HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity …
(HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity …
Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
Thirteen patients with acute myeloid leukemia, 5 with active disease, 2 in molecular relapse,
and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) …
and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) …
Natural killer cells as allogeneic effectors in adoptive cancer immunotherapy
KB Lupo, S Matosevic - Cancers, 2019 - mdpi.com
Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …
How I treat relapsed childhood acute lymphoblastic leukemia
The most common cause of treatment failure in childhood acute lymphoblastic leukemia
(ALL) remains relapse, occurring in∼ 15%-20% of patients. Survival of relapsed patients …
(ALL) remains relapse, occurring in∼ 15%-20% of patients. Survival of relapsed patients …