The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Zika virus infects human cortical neural progenitors and attenuates their growth

H Tang, C Hammack, SC Ogden, Z Wen, X Qian, Y Li… - Cell stem cell, 2016 - cell.com
The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and
microcephaly is an urgent global health concern. The direct target cells of ZIKV in the …

Zika virus: new clinical syndromes and its emergence in the western hemisphere

HM Lazear, MS Diamond - Journal of virology, 2016 - Am Soc Microbiol
Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of
outbreaks accompanied by unexpectedly severe clinical complications brought this virus …

Zika virus infects human placental macrophages

KM Quicke, JR Bowen, EL Johnson, CE McDonald… - Cell host & …, 2016 - cell.com
The recent Zika virus (ZIKV) outbreak in Brazil has been directly linked to increased cases of
microcephaly in newborns. Current evidence indicates that ZIKV is transmitted vertically from …

Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in∼ 40% of patients

A Gervais, F Rovida, MA Avanzini, S Croce… - Journal of Experimental …, 2023 - rupress.org
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …

West Nile virus: an update on pathobiology, epidemiology, diagnostics, control and “one health” implications

G Habarugira, WW Suen, J Hobson-Peters, RA Hall… - Pathogens, 2020 - mdpi.com
West Nile virus (WNV) is an important zoonotic flavivirus responsible for mild fever to severe,
lethal neuroinvasive disease in humans, horses, birds, and other wildlife species. Since its …

Modified vaccinia virus Ankara: history, value in basic research, and current perspectives for vaccine development

A Volz, G Sutter - Advances in virus research, 2017 - Elsevier
Abstract Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation
vaccine against smallpox and serves as a potent vector system for development of new …

[BOOK][B] Practical handbook of microbiology

LH Green, E Goldman - 2021 - books.google.com
Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …