In addition to their many functions in the healthy central nervous system (CNS), astrocytes
respond to CNS damage and disease through a process called “reactivity.” Recent evidence …

Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …

Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …

Brain metastasis (BrM) is a common malignancy, predominantly originating from lung,
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …

Brain metastases (BrMs) evade the immune response to develop in the brain, yet the
mechanisms of BrM immune evasion remains unclear. This study shows that brain …

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and
molecular biology research. However, it was still challenging for conventional angle …

Immune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of
patients with colorectal cancer (CRC). However, the dis-satisfactory response rate and the …

Over the last two decades, the diagnosis and treatment of breast cancer patients have
considerably improved. However, brain metastases remain a major clinical challenge and a …

Alzheimer's disease (AD) is one of the most debilitating age-related disorders that affect
people globally. It impacts social and cognitive behavior of the individual and is …

Tumor necrosis factor (TNF) has been recognized as an immune activation factor in tumor
immunotherapy. Our study demonstrated that TNF blockade markedly enhanced the …