Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology

LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Structure and function of human matrix metalloproteinases

H Laronha, J Caldeira - Cells, 2020 - mdpi.com
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant
molecule is collagen. This protein in triple helical conformation is highly resistant to …

[HTML][HTML] The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis

A Mukherjee, B Das - Biomaterials and Biosystems, 2024 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …

Matrix metalloproteinases in chronic obstructive pulmonary disease

ME Christopoulou, E Papakonstantinou… - International Journal of …, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …

[HTML][HTML] Regulation and function of matrix metalloproteinase-13 in cancer progression and metastasis

S Li, DM Pritchard, LG Yu - Cancers, 2022 - mdpi.com
Simple Summary MMP-13 is an enzyme that can digest and disrupt the tissue structures
surrounding epithelial cells that line the surface of many internal organs, as well as the …

MMPs as potential molecular target in epithelial-to-mesenchymal transition driven COPD progression

H Agraval, K Kandhari, UCS Yadav - Life Sciences, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of develo** lung cancer is six times greater in individuals with COPD …

Long‐lived second near‐infrared luminescent probes: An emerging role in time‐resolved luminescence bioimaging and biosensing

R Feng, G Li, CN Ko, Z Zhang, JB Wan… - Small …, 2023 - Wiley Online Library
Luminescence bioimaging and biosensing in the second near‐infrared (NIR‐II) spectral
window (1,000–1,700 nm wavelengths) is a newly emerging technique that is extensively …

Matrix Metalloproteinases in the periodontium—vital in tissue turnover and unfortunate in periodontitis

D Radzki, A Negri, A Kusiak, M Obuchowski - International Journal of …, 2024 - mdpi.com
The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular
network present within all tissues and organs, forming the foundation on which cells sit, and …

Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine

CD van der Heide, SU Dalm - European Journal of Nuclear Medicine and …, 2022 - Springer
Targeted radionuclide theranostics is becoming more and more prominent in clinical
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …

Molecular imaging of matrix metalloproteinase-2 in atherosclerosis using a smart multifunctional PET/MRI nanoparticle

Y Tu, X Ma, H Chen, Y Fan, L Jiang… - International …, 2022 - pmc.ncbi.nlm.nih.gov
Background Matrix metalloproteinases from macrophages are important intraplaque
components that play pivotal roles in plaque progression and regression. This study sought …