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Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Structure and function of human matrix metalloproteinases
H Laronha, J Caldeira - Cells, 2020 - mdpi.com
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant
molecule is collagen. This protein in triple helical conformation is highly resistant to …
molecule is collagen. This protein in triple helical conformation is highly resistant to …
[HTML][HTML] The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …
Matrix metalloproteinases in chronic obstructive pulmonary disease
ME Christopoulou, E Papakonstantinou… - International Journal of …, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …
[HTML][HTML] Regulation and function of matrix metalloproteinase-13 in cancer progression and metastasis
Simple Summary MMP-13 is an enzyme that can digest and disrupt the tissue structures
surrounding epithelial cells that line the surface of many internal organs, as well as the …
surrounding epithelial cells that line the surface of many internal organs, as well as the …
MMPs as potential molecular target in epithelial-to-mesenchymal transition driven COPD progression
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of develo** lung cancer is six times greater in individuals with COPD …
globally and the risk of develo** lung cancer is six times greater in individuals with COPD …
Long‐lived second near‐infrared luminescent probes: An emerging role in time‐resolved luminescence bioimaging and biosensing
Luminescence bioimaging and biosensing in the second near‐infrared (NIR‐II) spectral
window (1,000–1,700 nm wavelengths) is a newly emerging technique that is extensively …
window (1,000–1,700 nm wavelengths) is a newly emerging technique that is extensively …
Matrix Metalloproteinases in the periodontium—vital in tissue turnover and unfortunate in periodontitis
The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular
network present within all tissues and organs, forming the foundation on which cells sit, and …
network present within all tissues and organs, forming the foundation on which cells sit, and …
Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine
CD van der Heide, SU Dalm - European Journal of Nuclear Medicine and …, 2022 - Springer
Targeted radionuclide theranostics is becoming more and more prominent in clinical
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …
Molecular imaging of matrix metalloproteinase-2 in atherosclerosis using a smart multifunctional PET/MRI nanoparticle
Background Matrix metalloproteinases from macrophages are important intraplaque
components that play pivotal roles in plaque progression and regression. This study sought …
components that play pivotal roles in plaque progression and regression. This study sought …