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Growth hormone—past, present and future
MB Ranke, JM Wit - Nature Reviews Endocrinology, 2018 - nature.com
Growth hormone (GH) research and its clinical application for the treatment of growth
disorders span more than a century. During the first half of the 20th century, clinical …
disorders span more than a century. During the first half of the 20th century, clinical …
International consensus guideline on small for gestational age: etiology and management from infancy to early adulthood
ACS Hokken-Koelega, M van der Steen… - Endocrine …, 2023 - academic.oup.com
Abstract This International Consensus Guideline was developed by experts in the field of
small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus …
small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus …
Rare and low-frequency coding variants alter human adult height
Height is a highly heritable, classic polygenic trait with approximately 700 common
associated variants identified through genome-wide association studies so far. Here, we …
associated variants identified through genome-wide association studies so far. Here, we …
Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis
Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of
bone remodelling and metabolism and have an essential role in the achievement and …
bone remodelling and metabolism and have an essential role in the achievement and …
40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …
Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications
MJJ Finken, M van der Steen, CCJ Smeets… - Endocrine …, 2018 - academic.oup.com
Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
The pregnancy-associated plasma protein-A (PAPP-A) story
CA Conover, C Oxvig - Endocrine reviews, 2023 - academic.oup.com
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a
placental protein of unknown function, present at high concentrations in the circulation of …
placental protein of unknown function, present at high concentrations in the circulation of …
Disorders of IGFs and IGF-1R signaling pathways
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …
regulate multiple physiological processes, including mammalian development, metabolism …
[HTML][HTML] IGF2: Development, Genetic and Epigenetic Abnormalities
In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …
knockout mouse models, we have learnt much about the structure of this protein, its role and …
Management of growth disorders in puberty: GH, GnRHa, and aromatase inhibitors: a clinical review
Pubertal children with significant growth retardation represent a considerable therapeutic
challenge. In growth hormone (GH) deficiency, and in those without identifiable pathologies …
challenge. In growth hormone (GH) deficiency, and in those without identifiable pathologies …