Despite decades of research, we lack objective diagnostic or prognostic biomarkers of
mental health problems. A key reason for this limited progress is a reliance on the traditional …

Background Disruptions of axonal connectivity are thought to be a core pathophysiological
feature of psychotic illness, but whether they are present early in the illness, prior to …

Importance Identifying anatomy causally involved in psychosis could inform therapeutic
neuromodulation targets for schizophrenia. Objective To assess whether lesions that cause …

A growing understanding of the nature of brain function has led to increased interest in
interpreting the properties of large-scale brain networks. Methodological advances in …

The default network is widely implicated as a common neural substrate for self-generated
thought, such as remembering one's past (autobiographical memory) and imagining the …

Abstract Background Schizophrenia spectrum disorders (SSDs), which are characterized by
social cognitive deficits, have been associated with dysconnectivity in unimodal (eg, visual …

Psychosis has often been linked to abnormal cortical asymmetry, but prior results have been
inconsistent. Here, we applied a novel spectral shape analysis to characterize cortical shape …

Past work has shown that people with schizophrenia exhibit more cross-subject
heterogeneity in their functional connectivity patterns. However, it remains unclear whether …

Background: Deficits in the hippocampus are a consistent finding in schizophrenia and have
also been demonstrated in early-stage psychosis. Moreover, alterations in hippocampal …

Personality neuroscience aims to understand the associations of brain structure and function
with stable patterns of thought, behavior, emotion, and motivation. One broad personality …