Synthetic oligonucleotides (ONs) are being investigated for various therapeutic and
diagnostic applications. The interest in ONs arises because of their capability to cause …

DNA self‐assembly has proven to be a highly versatile tool for engineering complex and
dynamic biocompatible nanostructures from the bottom up with a wide range of potential …

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake
is dependent on the density of the oligonucleotide loading on the surface of the particles …

Small interfering RNAs offer novel opportunities to inhibit gene expression in a highly
selective and efficient manner but depend on cytosolic translocation with synthetic delivery …

The use of synthetic oligonucleotides and their mimics to inhibit gene expression by
hybridizing with their target sequences has been hindered by their poor cellular uptake and …

Conjugation of a lipid moiety via “click chemistry” potentiates the cellular uptake of
oligonucleotides and allows their intracellular delivery. These nontoxic lipid conjugates …

DNA repair enzymes play a vital role in the maintenance of genomic integrity, and the
development of multiple diseases. Investigation of DNA repair enzymes is of great …

The specific 1, 3 dipolar Hüisgen cycloaddition reaction known as 'click-reaction'between
azide and alkyne groups is employed for the synthesis of peptide–oligonucleotide …

The reaction of maleimide-containing compounds with 2, 5-dimethylfuran gives a mixture of
exo and endo isomers from which the exo cycloadduct can be easily isolated taking …

Antisense oligonucleotides (ASOs) are short, single-stranded nucleic acid molecules that
alter gene expression. However, their transport into appropriate cellular compartments is a …