Hemoglobin-expressing erythrocytes (red blood cells) act as fundamental metabolic
regulators by providing oxygen to cells and tissues throughout the body. Whereas the vital …

Thyroid hormone receptor α1 (TRα1) mediates the genomic actions of thyroid hormone (T3).
The biology of TRα1 in growth and development has been well studied, but the functional …

Nuclear receptors (NRs), are a wide family of ligand-regulated transcription factors sharing a
common modular structure composed by an N-terminal domain and a ligand-binding …

Tetrabromobisphenol A (TBBPA), a ubiquitous environmental pollutant, has been implicated
in developmental toxicity of aquatic animals. However, the impact of TBBPA on development …

Context Thyroid dysfunction is associated with higher anemia prevalence, although
causality remains unclear. Objective This study aimed to investigate the association …

Hormone-dependent activation of enhancers includes histone hyperacetylation and
mediator recruitment. Histone hyperacetylation is mostly explained by a bimodal switch …

Hyperthyroidism is a well-known trigger of high bone turnover that can lead to the
development of secondary osteoporosis. Previously, we have shown that blocking bone …

Background: The thyroid hormone triiodothyronine (T3) is critical for vertebrate development
and affects the function of many adult tissues and organs. Its genomic effects are mediated …

Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone.
Mutations of THRA gene cause a human disease known as resistance to thyroid hormone …

Background: Mutations of thyroid hormone receptor α (TRα1) result in resistance to thyroid
hormone (RTHα), exhibiting symptoms of retarded growth, delayed bone maturation …