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Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …
genomic landscapes and biological functions, the treatment of PCa continues to improve …
Current trends and challenges in cancer management and therapy using designer nanomaterials
Nanotechnology has the potential to circumvent several drawbacks of conventional
therapeutic formulations. In fact, significant strides have been made towards the application …
therapeutic formulations. In fact, significant strides have been made towards the application …
Polymersome-based protein drug delivery–quo vadis?
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …
approaches and represent one of the fastest growing families of drugs. While many of these …
Current use of PSMA–PET in prostate cancer management
Currently, the findings of imaging procedures used for detection or staging of prostate
cancer depend on morphology of lymph nodes or bone metabolism and do not always meet …
cancer depend on morphology of lymph nodes or bone metabolism and do not always meet …
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …
field has experienced an exponential growth since early 2000's. The path to the …
The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
A Afshar-Oromieh, E Avtzi, FL Giesel… - European journal of …, 2015 - Springer
Purpose Since the introduction of positron emission tomography (PET) imaging with 68 Ga-
PSMA-HBED-CC (= 68 Ga-DKFZ-PSMA-11), this method has been regarded as a significant …
PSMA-HBED-CC (= 68 Ga-DKFZ-PSMA-11), this method has been regarded as a significant …
Preclinical evaluation of a tailor-made DOTA-conjugated PSMA inhibitor with optimized linker moiety for imaging and endoradiotherapy of prostate cancer
M Benešová, M Schäfer, U Bauder-Wüst… - Journal of Nuclear …, 2015 - jnm.snmjournals.org
Despite many advances in the past years, the treatment of metastatic prostate cancer still
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
68Ga-and 177Lu-labeled PSMA I&T: optimization of a PSMA-targeted theranostic concept and first proof-of-concept human studies
M Weineisen, M Schottelius, J Simecek… - Journal of Nuclear …, 2015 - jnm.snmjournals.org
On the basis of the high and consistent expression of prostate-specific membrane antigen
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …
Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
A Afshar-Oromieh, CM Zechmann, A Malcher… - European journal of …, 2014 - Springer
Purpose Positron emission tomography (PET) with choline tracers has found widespread
use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased …
use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased …
Two decades of SPECT/CT–the coming of age of a technology: an updated review of literature evidence
Purpose Single-photon emission computed tomography (SPECT) combined with computed
tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago …
tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago …