Biologically active compounds play a key role in the fight against diseases affecting both
human and animal living organisms, as well as plants. Finding out about new molecules …

As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …

As we know that, Oxadiazole or furadi azole ring containing derivatives are an important
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …

Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial
protein of cytoskeleton that maintains essential cellular functions including cell division as …

The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …

Bacterial infections, particularly those associated with methicillin‐resistant Staphylococcus
aureus (MRSA) and vancomycin‐resistant Enterococcus (VRE), threaten public health and …

Due to their potential as leads for various therapeutic applications, including as antimitotic
and antiparasitic agents, the development of tubulin inhibitors offers promise for drug …

A three-component tandem protocol involving the reactions of bis (benzohydrazides),
aromatic aldehydes and chloramine trihydrate yielded a new series of bis (1, 3, 4 …

Due to the three domains of the colchicine-site which is conducive to the combination with
small molecule compounds, colchicine-site on the tubulin has become a common target for …