Methods for the study of innate immunity in Drosophila melanogaster

K Troha, N Buchon - Wiley Interdisciplinary Reviews …, 2019‏ - Wiley Online Library
From flies to humans, many components of the innate immune system have been conserved
during metazoan evolution. This foundational observation has allowed us to develop …

Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

S Seal, G Dharmarajan, I Khan - Elife, 2021‏ - elifesciences.org
Researchers worldwide are repeatedly warning us against future zoonotic diseases
resulting from humankind's insurgence into natural ecosystems. The same zoonotic …

Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters

J De Lorgeril, A Lucasson, B Petton, E Toulza… - Nature …, 2018‏ - nature.com
Infectious diseases are mostly explored using reductionist approaches despite repeated
evidence showing them to be strongly influenced by numerous interacting host and …

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

MA Hanson, A Dostálová, C Ceroni, M Poidevin… - elife, 2019‏ - elifesciences.org
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading
microorganisms. These short, cationic peptides have been implicated in many biological …

Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance

A Marra, MA Hanson, S Kondo, B Erkosar, B Lemaitre - MBio, 2021‏ - journals.asm.org
The gut microbiota affects the physiology and metabolism of animals and its alteration can
lead to diseases such as gut dysplasia or metabolic disorders. Several reports have shown …

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster

K Troha, JH Im, J Revah, BP Lazzaro… - PLoS …, 2018‏ - journals.plos.org
Host responses to infection encompass many processes in addition to activation of the
immune system, including metabolic adaptations, stress responses, tissue repair, and other …

A sustained immune response supports long-term antiviral immune priming in the Pacific oyster, Crassostrea gigas

M Lafont, A Vergnes, J Vidal-Dupiol, J de Lorgeril… - MBio, 2020‏ - journals.asm.org
Over the last decade, innate immune priming has been evidenced in many invertebrate
phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate …

Antibiotic-induced population fluctuations and stochastic clearance of bacteria

J Coates, BR Park, D Le, E Şimşek, W Chaudhry… - Elife, 2018‏ - elifesciences.org
Effective antibiotic use that minimizes treatment failures remains a challenge. A better
understanding of how bacterial populations respond to antibiotics is necessary. Previous …

Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses

L Wang, L Tracy, W Su, F Yang, Y Feng, N Silverman… - Nature …, 2022‏ - nature.com
Retrotransposons are one type of mobile genetic element that abundantly reside in the
genomes of nearly all animals. Their uncontrolled activation is linked to sterility, cancer and …

[HTML][HTML] Interactive effects of elevated temperature and Photobacterium swingsii infection on the survival and immune response of marine mussels (Perna canaliculus) …

A Azizan, L Venter, J Zhang, T Young… - Marine Environmental …, 2024‏ - Elsevier
Abstract The New Zealand Greenshell™ mussel (Perna canaliculus) is an economically
important aquaculture species. Prolonged increases in seawater temperature above mussel …