Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

Salmonella is a major foodborne pathogen and a leading cause of gastroenteritis in humans
and animals. Salmonella is highly pathogenic and encompasses more than 2600 …

Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …

Many species, including humans, host communities of symbiotic microbes. There is a vast
literature on the ways these microbiomes affect hosts, but here we argue for an increased …

Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

The mammalian gut is inhabited by a massive and complicated microbial community, in
which the host achieves a stable symbiotic environment through the interdependence …