Structure and dynamics of interfacial peptides and proteins from vibrational sum-frequency generation spectroscopy

S Hosseinpour, SJ Roeters, M Bonn, W Peukert… - Chemical …, 2020 - ACS Publications
Proteins at interfaces play important roles in cell biology, immunology, bioengineering, and
biomimetic material design. Many biological processes are based on interfacial protein …

Surface-induced protein aggregation and particle formation in biologics: current understanding of mechanisms, detection and mitigation strategies

MRG Kopp, F Grigolato, D Zürcher, TK Das… - Journal of …, 2023 - Elsevier
Protein stability against aggregation is a major quality concern for the production of safe and
effective biopharmaceuticals. Amongst the different drivers of protein aggregation …

Effects of ultrasound frequency mode on myofibrillar protein structure and emulsifying properties

J Chen, X Zhang, S Xue, X Xu - International Journal of Biological …, 2020 - Elsevier
In this study, different ultrasound frequencies, including 20 kHz, 23 kHz, and 20/23 kHz,
were applied for the treatment of myofibrillar protein (MP) with different protein …

Science and art of protein formulation development

W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Probing orientations and conformations of peptides and proteins at buried interfaces

W Guo, T Lu, Z Gandhi, Z Chen - The Journal of Physical …, 2021 - ACS Publications
Molecular structures of peptides/proteins at interfaces determine their interfacial properties,
which play important roles in many applications. It is difficult to probe interfacial …

Flotation surface chemistry of water-soluble salt minerals: from experimental results to new perspectives

K Sun, CV Nguyen, NN Nguyen, AV Nguyen - Advances in Colloid and …, 2022 - Elsevier
The flotation separation of water-soluble salt minerals has to be conducted under the
condition of saturation in brines which represents a challenging but exciting topic of colloid …

Adsorption and aggregation of monoclonal antibodies at silicone oil–water interfaces

A Kannan, IC Shieh, PG Negulescu… - Molecular …, 2021 - ACS Publications
Monoclonal antibody (mAb) therapies are rapidly growing for the treatment of various
diseases like cancer and autoimmune disorders. Many mAb drug products are sold as …

Why are water droplets highly mobile on nanostructured oil-impregnated surfaces?

C Zhang, S Adera, J Aizenberg… - ACS Applied Materials & …, 2021 - ACS Publications
Porous lubricated surfaces (aka slippery liquid-infused porous surfaces, SLIPS) have been
demonstrated to repel various liquids. The origin of this repellency, however, is not fully …

Stress factors in primary packaging, transportation and handling of protein drug products and their impact on product quality

LO Narhi, DK Chou, TR Christian, S Gibson… - Journal of …, 2022 - Elsevier
Protein-based biologic drugs encounter a variety of stress factors during drug substance
(DS) and drug product (DP) manufacturing, and the subsequent steps that result in clinical …

Development of syringes and vials for delivery of biologics: current challenges and innovative solutions

S Yoneda, T Torisu, S Uchiyama - Expert Opinion on Drug Delivery, 2021 - Taylor & Francis
Introduction Several new biopharmaceutical dosage forms have developed over time, such
as lyophilized vial, liquid vial, and liquid prefilled syringe formulations. This review …