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Structure and dynamics of interfacial peptides and proteins from vibrational sum-frequency generation spectroscopy
Proteins at interfaces play important roles in cell biology, immunology, bioengineering, and
biomimetic material design. Many biological processes are based on interfacial protein …
biomimetic material design. Many biological processes are based on interfacial protein …
Surface-induced protein aggregation and particle formation in biologics: current understanding of mechanisms, detection and mitigation strategies
Protein stability against aggregation is a major quality concern for the production of safe and
effective biopharmaceuticals. Amongst the different drivers of protein aggregation …
effective biopharmaceuticals. Amongst the different drivers of protein aggregation …
Effects of ultrasound frequency mode on myofibrillar protein structure and emulsifying properties
In this study, different ultrasound frequencies, including 20 kHz, 23 kHz, and 20/23 kHz,
were applied for the treatment of myofibrillar protein (MP) with different protein …
were applied for the treatment of myofibrillar protein (MP) with different protein …
Science and art of protein formulation development
W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …
expected to grow steadily over the next decade. Development of a commercial protein …
Probing orientations and conformations of peptides and proteins at buried interfaces
Molecular structures of peptides/proteins at interfaces determine their interfacial properties,
which play important roles in many applications. It is difficult to probe interfacial …
which play important roles in many applications. It is difficult to probe interfacial …
Flotation surface chemistry of water-soluble salt minerals: from experimental results to new perspectives
The flotation separation of water-soluble salt minerals has to be conducted under the
condition of saturation in brines which represents a challenging but exciting topic of colloid …
condition of saturation in brines which represents a challenging but exciting topic of colloid …
Adsorption and aggregation of monoclonal antibodies at silicone oil–water interfaces
Monoclonal antibody (mAb) therapies are rapidly growing for the treatment of various
diseases like cancer and autoimmune disorders. Many mAb drug products are sold as …
diseases like cancer and autoimmune disorders. Many mAb drug products are sold as …
Why are water droplets highly mobile on nanostructured oil-impregnated surfaces?
Porous lubricated surfaces (aka slippery liquid-infused porous surfaces, SLIPS) have been
demonstrated to repel various liquids. The origin of this repellency, however, is not fully …
demonstrated to repel various liquids. The origin of this repellency, however, is not fully …
Stress factors in primary packaging, transportation and handling of protein drug products and their impact on product quality
LO Narhi, DK Chou, TR Christian, S Gibson… - Journal of …, 2022 - Elsevier
Protein-based biologic drugs encounter a variety of stress factors during drug substance
(DS) and drug product (DP) manufacturing, and the subsequent steps that result in clinical …
(DS) and drug product (DP) manufacturing, and the subsequent steps that result in clinical …
Development of syringes and vials for delivery of biologics: current challenges and innovative solutions
S Yoneda, T Torisu, S Uchiyama - Expert Opinion on Drug Delivery, 2021 - Taylor & Francis
Introduction Several new biopharmaceutical dosage forms have developed over time, such
as lyophilized vial, liquid vial, and liquid prefilled syringe formulations. This review …
as lyophilized vial, liquid vial, and liquid prefilled syringe formulations. This review …