Background: The tumor suppressor PTEN serves as a negative regulator of PI3K/PTEN/Akt
signaling pathway that regulates cellular functions such as cell growth, differentiation …

Both mitosis and autophagy are highly regulated dynamic cellular processes and involve
various phosphorylation events catalysed by kinases, which play vital roles in almost all …

Proper organization of the mitotic spindle is key to genetic stability, but molecular
components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still …

In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III
mediates abscission, the process that physically separates daughter cells and completes …

The members of the PhosphoInositide-3 Kinase (PI3K) protein family are well-known
regulators of proliferative signals. By the generation of lipid second messengers, they …

Hematopoietic cancers are among the most common malignancies worldwide, which are
divided into different types depending on the origin of tumor cells. In recent years, the pivotal …

Background Alteration of signalling pathways regulating cell cycle progression is a common
feature of cancer cells. Several drugs targeting distinct phases of the cell cycle have been …

Due to sexual dimorphism in growth of penaeid shrimp, all-female cultivation is desirable for
the aquaculture industry. 17β-estradiol (E2) has the potential to induce the male-to-female …

Abstract Kinetochore associated 1 (KNTC1) encodes a kinetochore component in Rod-
Zwilch-ZW10 (RZZ) complex which is essential for the segregation of sister chromatids …

Genetic activation of the class I PI3K pathway is very common in cancer. This mostly results
from oncogenic mutations in PIK3CA, the gene encoding the ubiquitously expressed PI3Kα …