Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials

YF Chen, F Luh, YS Ho, Y Yen - Journal of biomedical science, 2024 - Springer
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids,
proteins, lipids, and metabolites. They mediate the exchange of substances between cells …

Role of exosomes in epithelial–mesenchymal transition

B Bhattacharya, S Nag, S Mukherjee… - ACS Applied Bio …, 2023 - ACS Publications
Epithelial–mesenchymal transition (EMT) is a fundamental process driving cancer
metastasis, transforming non-motile cells into a motile population that migrates to distant …

The Role of Non-Coding RNAs in Epigenetic Dysregulation in Glioblastoma Development

E Isachesku, C Braicu, R Pirlog, A Kocijancic… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GBM) is a primary brain tumor arising from glial cells. The tumor is highly
aggressive, the reason for which it has become the deadliest brain tumor type with the …

Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens

JS Bhardwaj, S Paliwal, G Singhvi, R Taliyan - Life Sciences, 2024 - Elsevier
Glioblastoma multiforme (GBM), also known as grade IV astrocytoma, is the most common
and deadly brain tumour. It has a poor prognosis and a low survival rate. GBM cells' …

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication

FM Filannino, MA Panaro, T Benameur… - International Journal of …, 2024 - mdpi.com
Cell-to-cell communication is essential for the appropriate development and maintenance of
homeostatic conditions in the central nervous system. Extracellular vesicles have recently …

Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases

M Ismail, J Liu, N Wang, D Zhang, C Qin, B Shi… - Biomaterials, 2025 - Elsevier
Despite the increasing global prevalence of neurological disorders, the development of
nanoparticle (NP) technologies for brain-targeted therapies confronts considerable …

Harnessing the potential of nanoengineered siRNAs carriers for target responsive glioma therapy: Recent progress and future opportunities

K Ahirwar, A Kumar, N Srivastava, SA Saraf… - International Journal of …, 2024 - Elsevier
Past scientific testimonials in the field of glioma research, the deadliest tumor among all
brain cancer types with the life span of 10-15 months after diagnosis is considered as …

Sustainable synthesis of Cr2O3 nanoparticles utilizing Rauvolfia tetraphylla root extract for lung cancer treatment

S Saha, G Dutta, S Mohanto, A Prabhu, B Ghosh… - Journal of Drug Delivery …, 2025 - Elsevier
Lung adenocarcinoma accounts for the leading cause of mortality worldwide, and it is
diagnosed only at advanced stages. Currently, existing treatment regimens including …

Silencing Exosomal circ102927 Inhibits Foot Melanoma Metastasis via Regulating Invasiveness, Epithelial-Mesenchymal Transition and Apoptosis

H Wan, L Zhong, T **a, D Zhang - Cancer Management and …, 2024 - Taylor & Francis
Background Exosomes contain abundant circular RNAs (circRNAs), playing an important
role in intercellular communication. However, the function and underlying molecular …

[HTML][HTML] Unlocking the Potential of Circulating miRNAs as Biomarkers in Glioblastoma

S Suvarnapathaki, A Serrano-Farias, JC Dudley… - Life, 2024 - mdpi.com
Using microRNAs (miRNAs) as potential circulating biomarkers in diagnosing and treating
glioblastoma (GBM) has garnered a lot of scientific and clinical impetus in the past decade …