A critical review of bottom-up proteomics: the good, the bad, and the future of this field
Proteomics is the field of study that includes the analysis of proteins, from either a basic
science prospective or a clinical one. Proteins can be investigated for their abundance …
science prospective or a clinical one. Proteins can be investigated for their abundance …
Ultraviolet photodissociation mass spectrometry for analysis of biological molecules
The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …
active areas of mass spectrometry owing to the broad applications of tandem mass …
An introduction to mass spectrometry-based proteomics
SR Shuken - Journal of Proteome Research, 2023 - ACS Publications
Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …
proteome. Because the foundations of mass spectrometry-based proteomics are complex …
Proteomic challenges: sample preparation techniques for microgram-quantity protein analysis from biological samples
P Feist, AB Hummon - International journal of molecular sciences, 2015 - mdpi.com
Proteins regulate many cellular functions and analyzing the presence and abundance of
proteins in biological samples are central focuses in proteomics. The discovery and …
proteins in biological samples are central focuses in proteomics. The discovery and …
SearchGUI: a highly adaptable common interface for proteomics search and de novo engines
Mass-spectrometry-based proteomics has become the standard approach for identifying and
quantifying proteins. A vital step consists of analyzing experimentally generated mass …
quantifying proteins. A vital step consists of analyzing experimentally generated mass …
From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites
T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …
the fungus to its environment. Although some of these natural products are promising …
Identification of Novel Microcystins Using High-Resolution MS and MSn with Python Code
Cyanotoxins called microcystins (MCs) are highly toxic and can be present in drinking water
sources. Determining the structure of MCs is paramount because of its effect on toxicity …
sources. Determining the structure of MCs is paramount because of its effect on toxicity …
Generation of antioxidative peptides from Atlantic sea cucumber using alcalase versus trypsin: In vitro activity, de novo sequencing, and in silico docking for in vivo …
Y Zhang, S He, É Bonneil, BK Simpson - Food Chemistry, 2020 - Elsevier
A comprehensive evaluation was conducted to compare the generation of antioxidative
peptides produced by alcalase versus trypsin from Atlantic sea cucumber. The in vitro …
peptides produced by alcalase versus trypsin from Atlantic sea cucumber. The in vitro …
Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows
Sequence database search engines are bioinformatics algorithms that identify peptides from
tandem mass spectra using a reference protein sequence database. Two decades of …
tandem mass spectra using a reference protein sequence database. Two decades of …
Phosphopeptide fragmentation and site localization by mass spectrometry: an update
CM Potel, S Lemeer, AJR Heck - Analytical chemistry, 2018 - ACS Publications
Pioneering work by, among others, the groups of Hunt and Mann at the start of this century
opened up the era of mass spectrometry (MS)-based phosphoproteomics. 1− 3 Through …
opened up the era of mass spectrometry (MS)-based phosphoproteomics. 1− 3 Through …