Epilepsy is a common and serious neurological disorder characterised by recurrent
spontaneous seizures. Frontline pharmacotherapy includes small-molecule antiseizure …

The brain is the most complex organ in the body, controlling our highest functions, as well as
regulating myriad processes which incorporate the entire physiological system. The effects …

Most of our knowledge on human CNS circuitry and related disorders originates from model
organisms. How well such data translate to the human CNS remains largely to be …

How structural and functional properties of synapses relate to each other is a fundamental
question in neuroscience. Electrophysiology has elucidated mechanisms of synaptic …

Retrotransposons are transposable elements (TEs) capable of “jum**” in germ, embryonic
and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE …

The evidence to guide clinicians regarding rationale polytherapy with current antiepileptic
drugs (AEDs) is lacking, and current practice recommendations are largely empirical. The …

Living acute brain slices provide a practical platform for imaging sialylation in human brain
pathology. However, the limited lifespan of acute brain slices has impeded the use of …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Rapid advances in neuroscience have provided remarkable breakthroughs in
understanding the brain on many fronts. Although promising, the role of these …

The increasing availability of quantitative data on the human brain is opening new avenues
to study neural function and dysfunction, thus bringing us closer and closer to the …