Targeted protein degradation is a pharmacological modality that is based on the induced
proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and …

Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …

Neurodegenerative diseases are characterized by the abnormal filamentous assembly of
specific proteins in the central nervous system. Human genetic studies have established a …

The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …

Recent advances in computational modelling of atomic systems, spanning molecules,
proteins, and materials, represent them as geometric graphs with atoms embedded as …

RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …

The dynamics of proteins are crucial for understanding their mechanisms. However,
computationally predicting protein dynamic information has proven challenging. Here, we …

Reversible and irreversible amyloids are two diverging cases of protein (mis) folding
associated with the cross-β motif in the protein folding and aggregation energy landscape …

NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat)
proteins that execute immune responses triggered by sensor NLRs. The resting state of …

Highlights•Single particle cryo-EM structure validation is an area of much-needed
development, and has seen significant recent advances.•The reported resolution of a single …