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[HTML][HTML] CRISPR/Cas9 platforms for genome editing in plants: developments and applications
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein9
(Cas9) genome editing system (CRISPR/Cas9) is adapted from the prokaryotic type II …
(Cas9) genome editing system (CRISPR/Cas9) is adapted from the prokaryotic type II …
Methods for optimizing CRISPR-Cas9 genome editing specificity
Advances in the development of delivery, repair, and specificity strategies for the CRISPR-
Cas9 genome engineering toolbox are hel** researchers understand gene function with …
Cas9 genome engineering toolbox are hel** researchers understand gene function with …
TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors
N Tang, C Cheng, X Zhang, M Qiao, N Li, W Mu… - JCI …, 2020 - pmc.ncbi.nlm.nih.gov
In recent years, chimeric antigen receptor–modified T cell (CAR T cell) therapy has proven to
be a promising approach against cancer. Nonetheless, this approach still faces multiple …
be a promising approach against cancer. Nonetheless, this approach still faces multiple …
Increasing the specificity of CRISPR systems with engineered RNA secondary structures
CRISPR (clustered regularly interspaced short palindromic repeat) systems have been
broadly adopted for basic science, biotechnology, and gene and cell therapy. In some …
broadly adopted for basic science, biotechnology, and gene and cell therapy. In some …
Pooled CRISPR screening with single-cell transcriptome readout
CRISPR-based genetic screens are accelerating biological discovery, but current methods
have inherent limitations. Widely used pooled screens are restricted to simple readouts …
have inherent limitations. Widely used pooled screens are restricted to simple readouts …
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a devastating disease affecting about 1 out of 5000
male births and caused by mutations in the dystrophin gene. Genome editing has the …
male births and caused by mutations in the dystrophin gene. Genome editing has the …
Non‐viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co‐delivery of Cas9 mRNA and sgRNA
CRISPR/Cas is a revolutionary gene editing technology with wide‐ranging utility. The safe,
non‐viral delivery of CRISPR/Cas components would greatly improve future therapeutic …
non‐viral delivery of CRISPR/Cas components would greatly improve future therapeutic …
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
M Matano, S Date, M Shimokawa, A Takano, M Fujii… - Nature medicine, 2015 - nature.com
Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in
the WNT, MAPK, TGF-β, TP53 and PI3K pathways,. Although these pathways influence …
the WNT, MAPK, TGF-β, TP53 and PI3K pathways,. Although these pathways influence …
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
Efficient intracellular delivery of proteins is needed to fully realize the potential of protein
therapeutics. Current methods of protein delivery commonly suffer from low tolerance for …
therapeutics. Current methods of protein delivery commonly suffer from low tolerance for …
Genome engineering using the CRISPR-Cas9 system
Targeted nucleases are powerful tools for mediating genome alteration with high precision.
The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short …
The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short …