Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia

H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Gestational diabetes and risk of cardiovascular disease up to 25 years after pregnancy: a retrospective cohort study

S McKenzie-Sampson, G Paradis, J Healy-Profitós… - Acta …, 2018 - Springer
Aims The risk of cardiovascular disease in women with gestational diabetes is poorly
understood. We sought to determine whether gestational diabetes increases the risk of …

Recurrent pre-eclampsia and subsequent cardiovascular risk

N Auger, WD Fraser, M Schnitzer, L Leduc… - Heart, 2017 - heart.bmj.com
Objective To determine the association between recurrent pre-eclampsia and long-term
cardiovascular hospitalisation. Methods This study identified cardiovascular hospitalisations …

Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy

CR Clark, RA Khalil - Biochemical Pharmacology, 2024 - Elsevier
Abstract Normal pregnancy (Norm-Preg) is associated with a slight reduction in blood
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …

Markers of vascular dysfunction after hypertensive disorders of pregnancy: a systematic review and meta-analysis

S Grand'Maison, L Pilote, M Okano, T Landry… - …, 2016 - Am Heart Assoc
Women with prior hypertensive disorders of pregnancy (HDP) are at twice the risk of
cardiovascular disease compared with women with prior normotensive pregnancy, possibly …

Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis

M Danielli, RC Thomas, CL Gillies, J Hu, K Khunti… - Heliyon, 2022 - cell.com
Pre-eclampsia is one of the most common pregnancy complications, and a major cause of
fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the …

The profiles of soluble adhesion molecules in the “great obstetrical syndromes”

N Docheva, R Romero, P Chaemsaithong… - The Journal of …, 2019 - Taylor & Francis
Objective: The objective of this study was to determine the profiles of maternal plasma
soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) …

Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy

M Zhu, Z Ren, JS Possomato-Vieira… - American Journal of …, 2016 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-related hypertensive disorder (HTN-Preg) with unclear
mechanism. An imbalance between antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt …