Matrix metalloproteinases in normal pregnancy and preeclampsia
J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia
H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …
Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia
JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …
to maternal and fetal morbidity and mortality. Although the causative factors and …
Gestational diabetes and risk of cardiovascular disease up to 25 years after pregnancy: a retrospective cohort study
Aims The risk of cardiovascular disease in women with gestational diabetes is poorly
understood. We sought to determine whether gestational diabetes increases the risk of …
understood. We sought to determine whether gestational diabetes increases the risk of …
Recurrent pre-eclampsia and subsequent cardiovascular risk
Objective To determine the association between recurrent pre-eclampsia and long-term
cardiovascular hospitalisation. Methods This study identified cardiovascular hospitalisations …
cardiovascular hospitalisation. Methods This study identified cardiovascular hospitalisations …
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy
CR Clark, RA Khalil - Biochemical Pharmacology, 2024 - Elsevier
Abstract Normal pregnancy (Norm-Preg) is associated with a slight reduction in blood
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …
Markers of vascular dysfunction after hypertensive disorders of pregnancy: a systematic review and meta-analysis
S Grand'Maison, L Pilote, M Okano, T Landry… - …, 2016 - Am Heart Assoc
Women with prior hypertensive disorders of pregnancy (HDP) are at twice the risk of
cardiovascular disease compared with women with prior normotensive pregnancy, possibly …
cardiovascular disease compared with women with prior normotensive pregnancy, possibly …
Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis
Pre-eclampsia is one of the most common pregnancy complications, and a major cause of
fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the …
fetal and maternal morbidity and mortality globally. Diagnosis currently takes place in the …
The profiles of soluble adhesion molecules in the “great obstetrical syndromes”
Objective: The objective of this study was to determine the profiles of maternal plasma
soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) …
soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) …
Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy
M Zhu, Z Ren, JS Possomato-Vieira… - American Journal of …, 2016 - journals.physiology.org
Preeclampsia (PE) is a pregnancy-related hypertensive disorder (HTN-Preg) with unclear
mechanism. An imbalance between antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt …
mechanism. An imbalance between antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt …