Immune checkpoint blockade has revolutionized the treatment of multiple tumor types,
including melanoma and nonmelanoma skin cancers. The use of immune checkpoint …

Immune checkpoint inhibitors (ICIs) constitute a pivotal class of immunotherapeutic drugs in
cancer treatment. However, their widespread clinical application has led to a notable surge …

Abstract Background Immune checkpoint inhibitors (ICIs) can cause profound immune-
related adverse events (irAEs). The host genetic background is likely to play a role in irAE …

Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-
producing pancreatic β-cells, leading to elimination of insulin production. The exact cause of …

Aims/hypothesis Activation of the transcription factor nuclear factor (NF)-κB by
proinflammatory cytokines plays an important role in beta cell demise in type 1 diabetes …

Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been
implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' …

Abstract Type 1 diabetes (T1D) is a complex multifactorial disease characterized by
autoimmune destruction of insulin-producing pancreatic β cells. Our understanding of the …

Hormone secretion from pancreatic islets is essential for glucose homeostasis, and loss or
dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are crucial …

Several highly conserved families of guidance molecules, including ephrins, Semaphorins,
Netrins, and Slits, play conserved and distinct roles in tissue remodeling during tissue …

There is evidence pointing towards shared etiological features between type 1 diabetes
(T1D) and type 2 diabetes (T2D) despite both phenotypes being considered genetically …