The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …

Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …

Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces
rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients.(2 …

Neurosecretory protein VGF (non-acronymic) belongs to the granin family of neuropeptides.
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …

Depression is a common mental illness, which is related to monoamine neurotransmitters
and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems …

Recent studies have implicated the endogenous opioid system in the antidepressant actions
of ketamine, but the underlying mechanisms remain unclear. We used a combination of …

Depression is a mental illness frequently accompanied by disordered energy metabolism. A
dysregulated hypothalamus pituitary adrenal axis response with aberrant glucocorticoids …