The study of plant mitochondria started in earnest around 1950 with the first isolations of
mitochondria from animal and plant tissues. The first 35 years were spent establishing the …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is
used for recycling cytoplasm to generate macromolecular building blocks and energy under …

Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded
protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We …

Mitophagy plays an important role in mitochondrial homeostasis by selective degradation of
mitochondria. During mitophagy, mitochondria should be fragmented to allow engulfment …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …