Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …

There are more than 70 distinct sarcomas, and this diversity complicates the development of
precision-based therapeutics for these cancers. Prospective comprehensive genomic …

Background Regorafenib has proven activity in patients with pretreated gastrointestinal
stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to …

Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing
neoplasms. Conventional chondrosarcomas are a continuum of disease based on the …

Bone-related diseases refer to a group of skeletal disorders that are characterized by bone
and cartilage destruction. Conventional approaches can regulate bone homeostasis to a …

Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum or
skull base. Chordomas are considered insensitive to conventional chemotherapy, and their …

Objective To develop and validate a radiomics signature based on magnetic resonance
imaging (MRI) from multicenter datasets for preoperative prediction of pathologic response …

Background Osteosarcoma, a primary malignant bone tumor derived from mesenchymal
tissue, is the most common type of pleomorphic tumor that occurs in children and …

Objectives: Identify early manifestations of Ewing sarcoma, distinguishing them from
common bone pathologies in adolescents. Differentiate between localized and metastatic …