Both preclinical and clinical studies implicate functional impairments of several neuroactive
metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential …

Cell–cell communication (CCC) is essential to how life forms and functions. However,
accurate, high-throughput map** of how expression of all genes in one cell affects …

Background The first 24 h of infection represent a critical time window in interactions
between pathogens and host tissue. However, it is not possible to study such early events in …

Dendritic cells (DCs), central participants in the allergic immune response, can capture and
present allergens leading to allergic inflammation in the immunopathogenesis of allergic …

Kidney transplantation significantly improves the survival of patients with end-stage kidney
disease (ESKD) compared to other forms of kidney replacement therapy. However, kidney …

Indoleamine 2, 3-dioxygenase 2 (IDO2) is a paralog of Indoleamine 2, 3-dioxygenase 1
(IDO1), a tryptophan-degrading enzyme producing immunomodulatory molecules. However …

Indoleamine 2, 3-dioxygenase 2 (IDO2) is a tryptophan-catabolizing enzyme and a homolog
of IDO1 with a distinct expression pattern compared with IDO1. In dendritic cells (DCs), IDO …

Background Madin-Darby canine kidney (MDCK) cells are a cellular matrix in the production
of influenza vaccines. The proliferation rate of MDCK cells is one of the critical factors that …

Background Head and neck squamous cancer (HNSCC) presents variable phenotype and
progression features. Clinically applicable, high-accuracy multifactorial prognostic models …