RNA modification, especially RNA methylation, is a critical posttranscriptional process
influencing cellular functions and disease progression, accounting for over 60% of all RNA …

Aims Major depressive disorder is a severe psychiatric disorder that afflicts~ 17% of the
world population. Neuroimaging investigations of depressed patients have consistently …

Genome-wide association studies (GWASs) of major depressive disorder (MDD) have
recently achieved extremely large sample sizes and yielded substantial numbers of genome …

Background LHPP was recently shown to be a risk gene for major depressive disorder.
LHPP has been proven to dephosphorylate the residues of histidine, serine, threonine, and …

Increasing evidence indicates that an altered immune system is closely linked to the
pathophysiology of anxiety disorders, and inhibition of neuroinflammation may represent an …

Anxiety disorder is one of the most common mental disorders worldwide, affecting nearly
30% of adults. However, its underlying molecular mechanisms are still unclear. Here we …

Phosphohistidine (pHis) is a reversible protein post-translational modification (PTM) that is
currently poorly understood. The PN bond in pHis is heat and acid-sensitive, making it more …

Background LHPP is a tumor suppressor protein associated with various malignancies like
liver, oral, pharyngeal, bladder, cervical, and gastric cancers through controlling various …

Background Dendritic spines are the sites of excitatory synapses on pyramidal neurons, and
their development is crucial for neural circuits and brain functions. The spine shape, size, or …

The recurrence of glioma after treatment has remained an intractable problem for many
years. Recently, numerous studies have explored the pivotal role of the mouse double …