Organ dysfunction or overt failure is a commonplace event in the critically ill affecting up to
70% of patients during their stay in the ICU. The outcome depends on the resolution of …

Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

The predictive performance of physiologically‐based pharmacokinetics (PBPK) models for
pharmacokinetics (PK) in renal impairment (RI) and hepatic impairment (HI) populations was …

Betaine is a kind of water-soluble quaternary amine-type alkaloid widely existing in food,
such as wheat germ, beet, spinach, shrimp and wolfberry. As an important methyl donor and …

Lactate levels and lactate clearance are known predictors of outcome in critically ill patients
in the intensive care unit (ICU). The prognostic value of lactate is not well established in liver …

Background & Aims Lactate has recently been reported to accumulate in the livers of
patients progressing from simple steatosis to non-alcoholic steatohepatitis (NASH) …

Lactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which
glucose can be fermented in the presence of oxygen to produce lactate) it was considered a …

In addition to the kidneys and lungs, the liver also plays an important role in the regulation of
the Acid-Base Equilibrium (ABE). The involvement of the liver in the regulation of ABE is …

Background Hepatocellular carcinoma (HCC) is one of the most lethal cancers. Nutrition‐
and life style‐associated risk factors are increasingly prevalent. Metformin, the mainstay of …

Biomarkers are an indicator of biologic or pathogenic processes, whose function is
indicating the presence/absence of disease or monitoring disease course and its response …