Abstract Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and
preventing tumor development. Over the years, p53 was found to exist in various isoforms …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

The tumour suppressor p53 is activated following genotoxic stress and regulates the
expression of target genes involved in the DNA damage response (DDR). The discovery that …

p53, first described four decades ago, is now established as a master regulator of cellular
stress response, the “guardian of the genome”. p53 contributes to biological robustness by …

All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …

Liquid–Liquid phase separation (LLPS) of p53 to form liquid condensates has been
implicated in cellular functions and dysfunctions. The p53 condensates may serve as …

Dysfunctional p53 formation and activity can result from aberrant expression and subcellular
localization of distinct p53 isoforms or aggregates. Endometrial carcinoma (EC) is a cancer …

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β
activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates …

Simple Summary TP53, the most frequently mutated gene in human cancers, has a key role
in the maintenance of the genetic stability and, thus, in preventing tumor development. The …

Understanding platelet protein functions facilitates better assessment of platelet disorders.
Megakaryocyte lineage-restricted human Disabled-2 knock-in (hDAB2-KI) mice are …