Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Exposure to micro-and nanoplastics (MNPs) has been implicated in potential cardiotoxicity.
However, in vitro models based on cardiomyocyte cell lines lack crucial cardiac …

Heart failure is a major health problem in which the heart is unable to pump enough blood to
meet the body's needs. It is a progressive disease that becomes more severe over time and …

Understanding the molecular mechanisms of epicardial epithelial-to-mesenchymal transition
(EMT), particularly in directing cell fate toward epicardial derivatives, is crucial for …

Introduction Myocardial fibrosis accompanies most cardiac conditions and can be reparative
or maladaptive. Transforming Growth Factor (TGF)-β is a potent fibrogenic mediator …

Revascularization is crucial for treating myocardial infarction (MI). Nitric oxide (NO), at an
appropriate concentration, is recognized as an ideal and potent pro-angiogenic factor …

Therapeutic angiogenesis represents a promising avenue to revascularize the ischemic
heart. Its limited success is partly due to our poor understanding of the cardiac stroma …

Pericyte dysfunction and loss contribute substantially to the destabilization and rupture of
atherosclerotic plaques. Protocatechuic aldehyde (PCAD), a natural polyphenol, exerts anti …

Simple Summary Hearing disorders, especially deafness, are highly debilitating diseases
that negatively affect the quality of life. Despite the high incidence, the underlying …