[PDF][PDF] A comprehensive review of opioid-induced hyperalgesia
M Lee, SM Silverman, H Hansen, VB Patel… - Pain physician, 2011 - academia.edu
As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …
was recognized that a potent analgesic such as morphine could actually result in an …
Cytokines in pain: harnessing endogenous anti-inflammatory signaling for improved pain management
AG Vanderwall, ED Milligan - Frontiers in immunology, 2019 - frontiersin.org
Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
Endogenous opioid systems alterations in pain and opioid use disorder
Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …
systems in regulating reward processing, mood, motivation, learning and memory …
Preoperative reduction of opioid use before total joint arthroplasty
Background The purpose of this study was to assess whether weaning of opioid use in the
preoperative period improved total joint arthroplasty (TJA) outcomes. Methods Forty-one …
preoperative period improved total joint arthroplasty (TJA) outcomes. Methods Forty-one …
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids …
clinical research was directed at the study of stereoselective neuronal actions of opioids …
Acute pain management in opioid-tolerant patients: a growing challenge
CA Huxtable, LJ Roberts, AA Somogyi… - … and intensive care, 2011 - journals.sagepub.com
In Australia and New Zealand, in parallel with other developed countries, the number of
patients prescribed opioids on a long-term basis has grown rapidly over the last decade …
patients prescribed opioids on a long-term basis has grown rapidly over the last decade …
[HTML][HTML] Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis
Background Opioid-induced hyperalgesia (OIH) is well documented in preclinical studies,
but findings of clinical studies are less consistent. The objective was to undertake a …
but findings of clinical studies are less consistent. The objective was to undertake a …
Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations
Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through
poorly understood brain stem pathways. The human counterpart, conditioned pain …
poorly understood brain stem pathways. The human counterpart, conditioned pain …
Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities
Visceral pain is a global term used to describe pain originating from the internal organs,
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …
Mechanisms, diagnosis, prevention and management of perioperative opioid-induced hyperalgesia
Opioid-induced hyperalgesia (OIH) occurs when opioids paradoxically enhance the pain
they are prescribed to ameliorate. To address a lack of perioperative awareness, we present …
they are prescribed to ameliorate. To address a lack of perioperative awareness, we present …