Global Literature Analysis of Organoid and Organ‐on‐Chip Research

J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2024 - Wiley Online Library
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Revisiting airflow and aerosol transport phenomena in the deep lungs with microfluidics

J Sznitman - Chemical Reviews, 2021 - ACS Publications
The dynamics of respiratory airflows and the associated transport mechanisms of inhaled
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …

A biomimetic human Lung‐on‐a‐Chip with colorful display of microphysiological breath

Y Zhu, L Sun, Y Wang, L Cai, Z Zhang… - Advanced …, 2022 - Wiley Online Library
Lung‐on‐a‐chip models hold great promise for disease modeling and drug screening.
Herein, inspired by the iridescence phenomenon of soap bubbles, a novel biomimetic 3D …

3D inkjet-bioprinted lung-on-a-chip

W Kim, Y Lee, D Kang, T Kwak, HR Lee… - … Biomaterials Science & …, 2023 - ACS Publications
There is an urgent need for physiologically relevant and customizable biochip models of
human lung tissue to provide a niche for lung disease modeling and drug efficacy. Although …

Biomimetic in vitro lung models: current challenges and future perspective

A Doryab, J Groll - Advanced Materials, 2023 - Wiley Online Library
As post‐COVID complications, chronic respiratory diseases are one of the foremost causes
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …

Understanding fibroblast-immune cell interactions via co-culture models and their role in asthma pathogenesis

F Thiam, SA Yazeedi, K Feng, S Phogat… - Frontiers in …, 2023 - frontiersin.org
Asthma is a chronic lung disease involving airway inflammation and fibrosis. Fibroblasts are
the main effector cells important for lung tissue production which becomes abnormal in …

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

A Sengupta, A Dorn, M Jamshidi, M Schwob… - Frontiers in …, 2023 - frontiersin.org
Prolonged exposure to environmental respirable toxicants can lead to the development and
worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary …

[HTML][HTML] Human lung cell models to study aerosol delivery–Considerations for model design and development

B Rothen-Rutishauser, M Gibb, R He… - European Journal of …, 2023 - Elsevier
Human lung tissue models range from simple monolayer cultures to more advanced three-
dimensional co-cultures. Each model system can address the interactions of different types …

An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics

V Kumar, SK Madhurakkat Perikamana… - … in bioengineering and …, 2022 - frontiersin.org
The gas exchange units of the lung, the alveoli, are mechanically active and undergo cyclic
deformation during breathing. The epithelial cells that line the alveoli contribute to lung …

Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models

CL Tan, Y Chan, M Candasamy, J Chellian… - European journal of …, 2022 - Elsevier
Chronic respiratory diseases have collectively become a major public health concern and
have now taken form as one of the leading causes of mortality worldwide. Most chronic …