Pulmonary hypertension
Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension
J Rodor, SH Chen, JP Scanlon… - Cardiovascular …, 2022 - academic.oup.com
Aims Endothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …
Pulmonary hypertension: a contemporary review
S Johnson, N Sommer, K Cox-Flaherty… - American journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …
associated with lung disease, and chronic thromboembolic PH cast new light on the …
Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment
Antenatal administration of extracellular vesicles from amniotic fluid stem cells (AFSC-EVs)
reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia …
reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia …
Pulmonary arterial hypertension patients have a proinflammatory gut microbiome and altered circulating microbial metabolites
Rationale: Inflammation drives pulmonary arterial hypertension (PAH). Gut dysbiosis causes
immune dysregulation and systemic inflammation by altering circulating microbial …
immune dysregulation and systemic inflammation by altering circulating microbial …
Harnessing big data to advance treatment and understanding of pulmonary hypertension
Pulmonary hypertension is a complex disease with multiple causes, corresponding to
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension
BACKGROUND: Inflammation is pathogenically implicated in pulmonary arterial
hypertension; however, it has not been adequately targeted therapeutically. We investigated …
hypertension; however, it has not been adequately targeted therapeutically. We investigated …
Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives
LM Becker, SH Chen, J Rodor… - Cardiovascular …, 2023 - academic.oup.com
Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …
crucial for homeostatic regulation of blood vessel physiology, but also play a key role in …
Experimental animal models of pulmonary hypertension: Development and challenges
XH Wu, JL Ma, D Ding, YJ Ma, YP Wei… - Animal Models and …, 2022 - Wiley Online Library
Pulmonary hypertension (PH) is clinically divided into 5 major types, characterized by
elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) …
elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) …