Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

The classical picture of enzyme catalysis relies on controlling the entropic and enthalpic
contributions by manipulating reaction barriers and co‐locating reactants and cofactors to …

Radicals are highly reactive, short-lived chemical species that normally react
indiscriminately with biological materials, and yet, nature has evolved thousands of enzymes …

Lysine 5, 6-aminomutase (5, 6-LAM) and ornithine 4, 5-aminomutase (4, 5-OAM) are two of
the rare enzymes that use assistance of two vitamins as cofactors. These enzymes employ …

Adenosylcobalamin (AdoCbl) serves as a source of reactive free radicals that are generated
by homolytic scission of the coenzyme's cobalt–carbon bond. AdoCbl-dependent enzymes …

5′-deoxyadenosylcobalamin (coenzyme B12, AdoCbl) serves as the cofactor for several
enzymes that play important roles in fermentation and catabolism. All of these enzymes …

B12-dependent enzymes employ radical species with exceptional prowess to catalyze some
of the most chemically challenging, thermodynamically unfavorable reactions. However …

High-energy radical species are widespread in biology as transient reaction intermediates
and free radicals. The control of these extremely reactive molecules is crucial to limit …

Electron spin echo envelope modulation (ESEEM) spectroscopy reveals several interactions
that serve to weaken the Co–C5′ bond, through stabilization of the cleaved state, thereby …

A computational study was performed on the experimentally elusive cyclisation step in the
cofactor pyridoxal 5′‐phosphate (PLP)‐dependent d‐ornithine 4, 5‐aminomutase (OAM) …