The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …

The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Motile cilia are miniature, propeller-like extensions, emanating from many cell types across
the body. Their coordinated beating generates a directional fluid flow, which is essential for …

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is
known to be impaired in neurological disorders, including Alzheimer's disease (AD). For this …

The brain develops and functions within a strictly controlled environment resulting from the
coordinated action of different cellular interfaces located between the blood and the …

Tumor-associated hydrocephalus (TAH) is a common and lethal complication of brain
metastases. Although other factors beyond mechanical obstructions have been suggested …

The primary cilium is a cellular organelle that is almost ubiquitous in eukaryotes, yet its
functions in vertebrates have been slow to emerge. The last fifteen years have been marked …