Stable feature selection for biomarker discovery

Z He, W Yu - Computational biology and chemistry, 2010 - Elsevier
Feature selection techniques have been used as the workhorse in biomarker discovery
applications for a long time. Surprisingly, the stability of feature selection with respect to …

In search of 'Omics'-based biomarkers to predict risk of frailty and its consequences in older individuals: the FRAILOMIC initiative

JD Erusalimsky, J Grillari, T Grune, P Jansen-Duerr… - Gerontology, 2016 - karger.com
An increase in the number of older people experiencing disability and dependence is a
critical aspect of the demographic change that will emerge within Europe due to the rise in …

[ΒΙΒΛΙΟ][B] Handbook of memetic algorithms

F Neri, C Cotta, P Moscato - 2011 - books.google.com
Memetic Algorithms (MAs) are computational intelligence structures combining multiple and
various operators in order to address optimization problems. The combination and …

[HTML][HTML] Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning

SN Dorman, K Baranova, JHM Knoll, BL Urquhart… - Molecular …, 2016 - Elsevier
Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been
related to changes in the genomic profile of tumors. We investigated correspondence …

Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology

D Beck, EE Nilsson, M Ben Maamar, MK Skinner - Scientific reports, 2022 - nature.com
Environmental toxicants have been shown to promote the epigenetic transgenerational
inheritance of disease through exposure specific epigenetic alterations in the germline. The …

Epigenome-wide association study for glyphosate induced transgenerational sperm DNA methylation and histone retention epigenetic biomarkers for disease

M Ben Maamar, D Beck, EE Nilsson, D Kubsad… - Epigenetics, 2021 - Taylor & Francis
The herbicide glyphosate has been shown to promote the epigenetic transgenerational
inheritance of pathology and disease in subsequent great-grand offspring (F3 generation) …

A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts

D Gomez-Cabrero, S Walter, I Abugessaisa… - Geroscience, 2021 - Springer
Phenotype-specific omic expression patterns in people with frailty could provide invaluable
insight into the underlying multi-systemic pathological processes and targets for intervention …

Ancestral plastics exposure induces transgenerational disease-specific sperm epigenome-wide association biomarkers

JLM Thorson, D Beck, M Ben Maamar… - Environmental …, 2021 - academic.oup.com
Plastic-derived compounds are one of the most frequent daily worldwide exposures.
Previously a mixture of plastic-derived toxicants composed of bisphenol A, bis (2-ethylhexyl) …

Current status of predictive biomarker development in metastatic renal cell carcinoma

G Fotia, M Stellato, V Guadalupi, P Sepe… - Current Oncology …, 2023 - Springer
Abstract Purpose of Review In this review, we analyze the current state of research in
development of new biomarkers that may be useful in managing metastatic renal cell …

Prognostic and predictive factors in advanced urothelial carcinoma treated with immune checkpoint inhibitors: A review of the current evidence

SE Rebuzzi, GL Banna, V Murianni, A Damassi… - Cancers, 2021 - mdpi.com
Simple Summary Despite immune checkpoint inhibitors'(ICIs) improved overall survival in
urothelial carcinoma patients, only a minority of them benefit from immunotherapy …