Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Inherited and age-related retinal degeneration is the hallmark of a large group of
heterogeneous diseases and is the main cause of untreatable blindness today. Genetic …

Abstract The Argus® II Retinal Prosthesis System (Second Sight Medical Products) is the
first prosthetic vision device to obtain regulatory approval in both Europe and the USA. As …

Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene
transfer. AAV serotype 2 (AAV2) is commonly used to deliver transgenes to retinal ganglion …

Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …

Optogenetics is a recent breakthrough in neuroscience, and one of the most promising
applications is the treatment of retinal degenerative diseases. Multiple clinical trials are …

Vision restoration is an ideal medical application for optogenetics, because the eye provides
direct optical access to the retina for stimulation. Optogenetic therapy could be used for …

Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …

Inherited and age-related retinal degenerative diseases cause progressive loss of rod and
cone photoreceptors, leading to blindness, but spare downstream retinal neurons, which …

Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …