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The quest to slow ageing through drug discovery
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
[HTML][HTML] Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer
Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
Guidelines for the use and interpretation of assays for monitoring autophagy
Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …
essential for demonstrating autophagy, either for the purposes of their own research, or in …
The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
H Yu, P Guo, X **e, Y Wang… - Journal of cellular and …, 2017 - Wiley Online Library
Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and
necrosis and results from iron‐dependent lipid peroxide accumulation. Ferroptotic cell death …
necrosis and results from iron‐dependent lipid peroxide accumulation. Ferroptotic cell death …