Genetic causes and modifiers of autism spectrum disorder

L Rylaarsdam, A Guemez-Gamboa - Frontiers in cellular …, 2019 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …

[HTML][HTML] Genetics of attention deficit hyperactivity disorder

SV Faraone, H Larsson - Molecular psychiatry, 2019 - nature.com
Decades of research show that genes play an vital role in the etiology of attention deficit
hyperactivity disorder (ADHD) and its comorbidity with other disorders. Family, twin, and …

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

D Demontis, RK Walters, J Martin, M Mattheisen… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Prevalence of attention-deficit/hyperactivity disorder in individuals with autism spectrum disorder: A meta-analysis

Y Rong, CJ Yang, Y **, Y Wang - Research in Autism Spectrum Disorders, 2021 - Elsevier
Background Comorbidity with attention-deficit/hyperactivity disorder (ADHD) is very common
in autism spectrum disorder (ASD), worsening the developmental trajectory of ASD. The …

Classification and prediction of brain disorders using functional connectivity: promising but challenging

Y Du, Z Fu, VD Calhoun - Frontiers in neuroscience, 2018 - frontiersin.org
Brain functional imaging data, especially functional magnetic resonance imaging (fMRI)
data, have been employed to reflect functional integration of the brain. Alteration in brain …

A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder

F Craig, F Margari, AR Legrottaglie… - Neuropsychiatric …, 2016 - Taylor & Francis
Executive dysfunction has been shown to be a promising endophenotype in
neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention …

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

B Devlin, JR Kelsoe, P Sklar, MJ Daly, MC O'Donovan… - Nature …, 2013 - nature.com
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

Cross-Disorder Group of the Psychiatric Genomics … - The Lancet, 2013 - Elsevier
BACKGROUND: Findings from family and twin studies suggest that genetic contributions to
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …

Research review: polygenic methods and their application to psychiatric traits

NR Wray, SH Lee, D Mehta… - Journal of child …, 2014 - Wiley Online Library
Background Despite evidence from twin and family studies for an important contribution of
genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly …

Pleiotropy in complex traits: challenges and strategies

N Solovieff, C Cotsapas, PH Lee, SM Purcell… - Nature Reviews …, 2013 - nature.com
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …