Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Monitoring the effects of daily activities on the physiological responses of the body calls for
wearable devices that can simultaneously track metabolic and haemodynamic parameters …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …

Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …

Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …