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[HTML][HTML] Allostery: allosteric cancer drivers and innovative allosteric drugs
Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …
A patent review of P2X7 receptor antagonists to treat inflammatory diseases (2018–present)
J Iqbal, S Bano, IA Khan, Q Huang - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
ABSTRACT Introduction The purinergic P2X7 receptor (P2X7R) is expressed on the surface
of many different types of cells, including immune cells. Targeting P2X7R with antagonists …
of many different types of cells, including immune cells. Targeting P2X7R with antagonists …
CBD and the 5-HT1A receptor: A medicinal and pharmacological review
C Alexander, J Jeon, K Nickerson, S Hassler… - Biochemical …, 2025 - Elsevier
Abstract Cannabidiol (CBD), a phytocannabinoid, has emerged as a promising candidate for
addressing a wide array of symptoms. It has the ability to bind multiple proteins and …
addressing a wide array of symptoms. It has the ability to bind multiple proteins and …
Gcoupler: An AI-enhanced tool unveiled Endogenous Intracellular Allosteric Modulators of Evolutionary Conserved GPCR-Gα Interface
Traditionally, the exogenous allosteric modulators of G protein-coupled receptors (GPCRs)
have been extensively investigated due to their pharmacological significance. However, to …
have been extensively investigated due to their pharmacological significance. However, to …
Allosteric modulator potentiates β2AR agonist–promoted bronchoprotection in asthma models
Asthma is a chronic inflammatory disease associated with episodic airway narrowing.
Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote—with limited efficacy …
Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote—with limited efficacy …
Artificial Intelligence Uncovers Evolutionarily Conserved Intracellular Allosteric Modulators of GPCR-Gα Interface
Traditionally, the exogenous allosteric modulators of G protein-coupled receptors (GPCRs)
have been extensively investigated due to their pharmacological significance. However, to …
have been extensively investigated due to their pharmacological significance. However, to …
[CITATION][C] Development of computational methods for ultra-large virtual screens
P Mishra - 2021 - Dissertation, Universität Freiburg …