The structure and mechanism of the bacterial type II secretion system

S Naskar, M Hohl, M Tassinari… - Molecular …, 2021 - Wiley Online Library
The type II secretion system (T2SS) is a multi‐protein complex used by many bacteria to
move substrates across their cell membrane. Substrates released into the environment …

Bacterial secretins: mechanisms of assembly and membrane targeting

YRO Silva, C Contreras‐Martel, P Macheboeuf… - Protein …, 2020 - Wiley Online Library
Secretion systems are employed by bacteria to transport macromolecules across
membranes without compromising their integrities. Processes including virulence …

Assembly mechanism of a Tad secretion system secretin-pilotin complex

M Tassinari, M Rudzite, A Filloux, HH Low - Nature Communications, 2023 - nature.com
The bacterial T ight ad herence S ecretion S ystem (TadSS) assembles surface pili that drive
cell adherence, biofilm formation and bacterial predation. The structure and mechanism of …

In vivo structure of the Legionella type II secretion system by electron cryotomography

D Ghosal, KW Kim, H Zheng, M Kaplan… - Nature …, 2019 - nature.com
The type II secretion system (T2SS) is a multiprotein envelope-spanning assembly that
translocates a wide range of virulence factors, enzymes and effectors through the outer …

CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae

SJ Weaver, DR Ortega, MH Sazinsky, TN Dalia… - Nature …, 2020 - nature.com
Natural transformation is the process by which bacteria take up genetic material from their
environment and integrate it into their genome by homologous recombination. It represents …

Insights into dynamics and gating properties of T2SS secretins

B Barbat, B Douzi, G Ball, M Tribout, K El Karkouri… - Science …, 2023 - science.org
Secretins are outer membrane (OM) channels found in various bacterial nanomachines that
secrete or assemble large extracellular structures. High-resolution 3D structures of type 2 …

Structural lessons on bacterial secretins

B Barbat, B Douzi, R Voulhoux - Biochimie, 2023 - Elsevier
To exchange and communicate with their surroundings, bacteria have evolved multiple
active and passive mechanisms for trans-envelope transport. Among the pore-forming …

Cold shock proteins improve E. coli cell‐free synthesis in terms of soluble yields of aggregation‐prone proteins

K Higuchi, T Yabuki, M Ito… - Biotechnology and …, 2020 - Wiley Online Library
Protein folding is usually slowed‐down at low temperatures, and thus low‐temperature
expression is an effective strategy to improve the soluble yield of aggregation‐prone …

Role of bacterial secretion systems and effector proteins–insights into Aeromonas pathogenicity mechanisms

J Matys, A Turska-Szewczuk… - Acta Biochimica …, 2020 - abp.ptbioch.edu.pl
Gram-negative bacteria have developed several nanomachine channels known as type II,
III, IV and VI secretion systems that enable export of effector proteins/toxins from the cytosol …

Comparative transcriptome and phenotype analysis revealed the role and mechanism of ompR in the virulence of fish pathogenic Aeromonas hydrophila

M Zhang, J Kang, B Wu, Y Qin, L Huang… - …, 2020 - Wiley Online Library
Aeromonas hydrophila B11 strain was isolated from diseased Anguilla japonica, which had
caused severe gill ulcers in farmed eel, causing huge economic losses. EnvZ‐OmpR is a …