Left atrial appendage: embryology, anatomy, physiology, arrhythmia and therapeutic intervention

N Naksuk, D Padmanabhan, V Yogeswaran… - JACC: Clinical …, 2016 - jacc.org
Known for the pathological connection to atrial fibrillation (AF), the left atrial appendage
(LAA) is the most common source of thromboembolism in patients with AF and may be an …

The left atrial appendage in humans: structure, physiology, and pathogenesis

N Karim, SY Ho, E Nicol, W Li, F Zemrak… - EP …, 2020 - academic.oup.com
For many years, the left atrial appendage (LAA) was considered a dormant embryological
remnant; however, it is a structurally complex and functional organ that contributes to cardiac …

Left atrial appendage closure and systemic homeostasis: the LAA HOMEOSTASIS study

D Lakkireddy, M Turagam, MR Afzal… - Journal of the American …, 2018 - jacc.org
Background: The impact of left atrial appendage (LAA) exclusion, comparing an epicardial
LAA or an endocardial LAA device, on systemic homeostasis remains unknown. Objectives …

Metabolomics of diabetes in pregnancy

CF McCabe, W Perng - Current diabetes reports, 2017 - Springer
Purpose of review The purpose of this review is to describe ways in which metabolomics
may enhance understanding of gestational diabetes mellitus (GDM) etiology and refine …

Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation

J Yang, H Tan, M Sun, R Chen, Z Jian… - Clinical and …, 2023 - Wiley Online Library
Background Atrial fibrillation (AF) is associated with an increased risk of thrombosis of the
left atrial appendage (LAA). However, the molecular mechanisms underlying this site …

[HTML][HTML] Percutaneous left atrial appendage occlusion: an emerging option in patients with atrial fibrillation at high risk of bleeding

G Cimmino, FS Loffredo, E Gallinoro, D Prozzo… - Medicina, 2021 - mdpi.com
Atrial fibrillation (AF) is a common cardiac arrhythmia with an estimated prevalence of 1% in
the general population. It is associated with an increased risk of ischemic stroke, silent …

Impact of left atrial appendage closure on cardiac functional and structural remodeling: a difference-in-difference analysis of propensity score matched samples

QT Phan, SY Shin, IS Cho, WS Lee, H Won… - Cardiology …, 2019 - journals.viamedica.pl
Background: Although the safety and efficacy of left atrial (LA) appendage (LAA) closure
(LAAC) in nonvalvular atrial fibrillation (NVAF) patients have been well documented in …

Metabolic effects of the left atrial appendage exclusion (the heart hormone study)

K Bartus, MA Elbey, SH Kanuri, R Lee… - Journal of …, 2022 - Wiley Online Library
Introduction The effect of epicardial left atrial appendage (LAA) occlusion therapy on lipid
and glucose metabolism in atrial fibrillation (AF) patients over the long‐term follow‐up are …

[HTML][HTML] The left atrial appendage and atrial fibrillation—A contemporary review

RM Sulague, T Whitham, LML Danganan… - Journal of Clinical …, 2023 - mdpi.com
In patients with atrial fibrillation, the left atrial appendage may serve as the site of thrombus
formation due to stasis that occurs within the appendage because of its shape and …

A review of the anatomical and histological attributes of the left atrial appendage with descriptive pathological examination of morphology and histology

M Hensey, L O'Neill, C Mahon, S Keane… - Journal of atrial …, 2018 - pmc.ncbi.nlm.nih.gov
The left atrial appendage (LAA) has a key role in the embolic complications of atrial
fibrillation (AF). It has been studied extensively, from recent interest in the thrombotic …