Considering sex as a biological variable will require a global shift in science culture

RM Shansky, AZ Murphy - Nature neuroscience, 2021 - nature.com
For over half a century, male rodents have been the default model organism in preclinical
neuroscience research, a convention that has likely contributed to higher rates of …

Towards the fully automated monitoring of ecological communities

M Besson, J Alison, K Bjerge, TE Gorochowski… - Ecology …, 2022 - Wiley Online Library
High‐resolution monitoring is fundamental to understand ecosystems dynamics in an era of
global change and biodiversity declines. While real‐time and automated monitoring of …

Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics

C Weinreb, JE Pearl, S Lin, MAM Osman, L Zhang… - Nature …, 2024 - nature.com
Keypoint tracking algorithms can flexibly quantify animal movement from videos obtained in
a wide variety of settings. However, it remains unclear how to parse continuous keypoint …

Survey of spiking in the mouse visual system reveals functional hierarchy

JH Siegle, X Jia, S Durand, S Gale, C Bennett… - Nature, 2021 - nature.com
The anatomy of the mammalian visual system, from the retina to the neocortex, is organized
hierarchically. However, direct observation of cellular-level functional interactions across this …

Multi-animal pose estimation, identification and tracking with DeepLabCut

J Lauer, M Zhou, S Ye, W Menegas, S Schneider… - Nature …, 2022 - nature.com
Estimating the pose of multiple animals is a challenging computer vision problem: frequent
interactions cause occlusions and complicate the association of detected keypoints to the …

[HTML][HTML] Large-scale two-photon calcium imaging in freely moving mice

W Zong, HA Obenhaus, ER Skytøen, H Eneqvist… - Cell, 2022 - cell.com
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Deep learning tools for the measurement of animal behavior in neuroscience

MW Mathis, A Mathis - Current opinion in neurobiology, 2020 - Elsevier
Highlights•Deep neural networks are shattering performance benchmarks in computer
vision for various tasks.•Using modern deep learning approaches (DNNs) in the lab is a …

DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

JM Graving, D Chae, H Naik, L Li, B Koger… - Elife, 2019 - elifesciences.org
Quantitative behavioral measurements are important for answering questions across
scientific disciplines—from neuroscience to ecology. State-of-the-art deep-learning methods …

A non-hallucinogenic LSD analog with therapeutic potential for mood disorders

V Lewis, EM Bonniwell, JK Lanham, A Ghaffari… - Cell reports, 2023 - cell.com
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion

X Liu, S Rao, W Chen, K Felix, J Ni, A Sahasrabudhe… - Nature …, 2023 - nature.com
We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable
optogenetic modulation of peripheral nerves in naturally behaving animals during persistent …